1999;151(iii-ix):1–101. Aniline exposure is associated with toxicity to the spleen which is characterized by splenomegaly, hyperplasia, fibrosis, and a variety of sarcomas on chronic exposure in rats. (, Photomicrographs of the thoracic spinal cord of rats after single injection of aniline at 4 weeks of age and post-treatment day 15. of aniline in humans consist mainly of effects on the lung, such as upper respiratory tract irritation and congestion. Prolonged exposure to the vapour or slight skin exposure over a period of time affects the nervous system and the blood, causing tiredness, loss of appetite, headache, and dizziness. Early indicators of aniline hydrochloride (AH) toxicity were investigated in male Fisher 344 rats for 1 or 4 weeks at dietary dose levels of 10, 30 or 100 mg/kg body weight (bw)/day (actual intake at least 6, 17 and 57 mg/kg). Repeated dose toxicity studies demonstrated that splenic toxicity of aniline is clearly associated with damage of erythrocytes in that the spleen is the organ responsible for the erythrocyte clearance. Aniline induces extracellular polymeric substance and aggregates formation in strain JA2. aniline aluminium salt. aniline dihydrofluoride. USA.gov. Food Chem Toxicol. 2013 Mar 15;267(3):276-83. doi: 10.1016/j.taap.2013.01.005. Chronic exposure may also result in effects on the blood. However, the molecular mechanism (s) of aniline-induced spleen toxicity is not understood well, previous studies have represented that aniline exposure results in iron overload and initiation of oxidative/nitrosative disorder stress and oxidative damage to proteins, lipids and … To understand the mechanism(s) of aniline-induced splenic toxicity, single and multiple (four and seven) doses of 1 mmol/kg of aniline hydrochloride(AH) were given in rats. Canadian Journal of Physiology and Pharmacology 2013 , 91 (3) , 228-235. 2014;147(4):R105–R117. Proteomic data reveal the up-regulation of envelope stress response proteins to aniline exposure. toxicity of aniline after inhalation exposure is insufficient, but haematotoxicity at very low concentrations (19-66 mg/m3) have been reported for rats. All of these events could initiate a fibrogenic and/or tumorigenic response in the spleen. (, Induction of signal transduction cascades and activation of transcription factors AP-1 and NF-B. 2005 Dec;35(10):783-835. doi: 10.1080/10408440500442384. Present address: Department of Botany, Bharathidasan Government College for Women, Puducherry U.T-605003, India. The wide database on aniline studies and specific investigations point to a low potency and an indirect mechanism of clastogenicity, mediated by erythrotoxicity followed by spleenic toxicity and compensatory extramedullary hematopoesis in the bone marrow of rats. Although microbial metabolism of aniline is well-studied, its toxic effects and physiological responses of microorganisms to aniline are largely unexplored. Germany)(Wiley-VCH Verlag GmbH & Co. KGaA, 2000. Strategies for the use of bio-indicators in the prediction of environmental damage should include mechanistic research. The toxicity of aniline derivatives towards Agmenellum quadruplicatum strain PR-6 indicated that the cyanobacterium was extremely sensitive to o-, m- and p-aminophenols, and phenylhydroxylamine. This review aimed at clarifying if aniline itself or one of its … The present study suggests that aniline triggers envelope stress; to counter this strain JA2 activates ESR pathway and EPS production. Activation of oxidative stress-responsive signaling pathways in early splenotoxic response of aniline. We use cookies to help provide and enhance our service and tailor content and ads. Epub 2010 Nov 8. 2004;81(1):198–215. [http://dx. Toxicol Appl Pharmacol. Aniline, phenylamine or aminobenzene is an organic compound with the formula C6H5NH2. Embryol. HHS Aniline exposure leads to neuron and spleen toxicity specifically and makes diverse neurological effects and sarcoma that is defined by splenomegaly, hyperplasia, and fibrosis and tumors formation at the end. Agmenellum quadruplicatum strain PR-6 and Oscillatoria sp. Pauluhn J. Subacute inhalation toxicity of aniline in rats: analysis of time-dependence and concentration-dependence of hematotoxic and splenic effects. The interaction of diamines and polyamines with the peroxidase-catalyzed metabolism of aromatic amines: a potential mechanism for the modulation of aniline toxicity. Khan M.F., Kannan S., Wang J. Activation of transcription factor AP-1 and mitogen-activated protein kinases in aniline-induced splenic toxicity. Elevated expression of cyclins, cyclin-dependent kinases (CDKs) and phosphorylation of pRB protein along with increases in A, B and CDK1 as a cell cycle regulatory proteins cyclins, and reduce in CDK inhibitors (p21 and p27) could be critical in cell cycle regulation, which contributes to tumorigenic response after aniline exposure. Aniline exposure leads to neuron and spleen toxicity specifically and makes diverse neurological effects and sarcoma that is defined by splenomegaly, hyperplasia, and fibrosis and tumors formation at the end. Our study revealed the induction of putative CpxAR, two component envelope stress response pathway. Clipboard, Search History, and several other advanced features are temporarily unavailable. Earlier we have shown that aniline exposure leads to increased nitration of proteins in the spleen. The consequential increased cell turnover and iron cycling in the bone marrow is discussed to encourage chromosomal damage … 1987 Aug;25(8):619-26. doi: 10.1016/0278-6915(87)90024-x. Excessive reactive oxygen species (ROS) derived from iron accumulation activate MAPKs and IKK. 2011 Jan 15;250(2):213-20. doi: 10.1016/j.taap.2010.10.026. Induction of base excision repair enzymes NTH1 and APE1 in rat spleen following aniline exposure. Mechanistic Study on Aniline-Induced Erythrocyte Toxicity. Epub 2013 Jan 23. http://dx.doi.org/10.1016/j.taap.2005.08.006, NCI CPTC Antibody Characterization Program. Dawson AH, Whyte IM. Pharmacol. Modick H., Weiss T., Dierkes G., Brüning T., Koch H.M. Ubiquitous presence of paracetamol in human urine: sources and implications. Male Sprague-Dawley rats were given 0.025, 0.05, 0.1, or 0.2 mmol/kg/d of NB in 0.5 ml of 0.25% agar by gavage for 4 d; control rats received the vehicle only. aniline monosulfate. Reproduction. 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