(4) EPA uses mathematical models, based on human and animal studies, to estimate the probability of a person developing cancer from breathing air containing a specified concentration of a chemical. IARC Monographs on the Identification of Carcinogenic Hazards to Humans. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an … In 1978, the results of a carcinogenesis bioassay in rats and mice given aniline hydrochloride were released. Aniline has been classified as very toxic in humans, with a probable oral lethal dose in humans at 50 to 500 milligrams per kilogram body weight (mg/kg). The approximate minimum lethal dose for a 150 lb. In mice, however, only a marginally positive … It is considered to have high acute toxicity, based on short-term animal tests in rats. Heart, kidney, and liver damage may also occur, possibly as secondary effects of hemolysis Considered a Non Threshold carcinogen : Aniline is a colourless, oily liquid which turns brown on exposure to light and air. However, benzidine has not been sold in the United States since the mid-1970s. Given new scientific evidence, it cannot be excluded that aniline ’s carcinogenic potential is due to damage to the genetic material of the cells. The same carcinogen can give rise to tumors of different kinds and locations, depending on the site of application, and a given type of tumor can be caused by different substances. ... Metolachlor can increase the incidence of liver tumors in rats and has been classified as a possible human carcinogen (Monsanto, 1991; Wilson and Takei, 1999; Heydens et al., 2010). This category is only used when sufficient indications of carcinogenicity for humans are available. The human carcinogen potency factor (q1*) for aniline is .026 (mg/kg/day)-1 for oral exposure. Classification of carcinogenicity: Overall summary evaluation of carcinogenic risk to humans is Group 3: The agent is not classifiable as to its carcinogenicity to humans. Aniline does, however, induce intrachromosomal recombination between repeated sequences in Saccharomyces cerevisiae, resulting in deletion (DEL) of intervening sequences. Although aniline is "only" a category 2 carcinogen (remember formaldehyde?) Ethanol is flammable and a dangerous fire risk. Learn about benzidine, exposure to which raises your risk of bladder cancer. It causes kidney, urethra, bladder, and hematological neoplasia. Until recently, these inadequate experiments plus the publication of a series of epidemiologic studies that exonerated aniline as a bladder carcinogen have led to the belief that aniline is not a carcinogen. GROUP 1: the agent may be a carcinogenic mixture for humans (proven carcinogen or certainly carcinogenic). The in vitro enzymatic metabolism of N-nitroso-N-methylaniline was investigated using cytochromes P450 2B1 and P450 2B2, isolated from liver microsomes of rats pretreated with phenobarbital (PB), reconstituted with NADPH-cytochrome P450 reductase and dilauroylphosphatidylcholine. Inhaling Aniline can irritate the nose and throat. Aniline is classified as a suspected carcinogen (carcinogen category 2) under the Classification, Labelling and Packaging Regulation (CLP) in the EU. Summary of Data Reported and Evaluation 5.1 Animal carcinogenicity data There is no adequate data to indicate that aniline is carcinogenic in experimental animals. Dietary Supplement Label Database (DSLD): The Dietary Supplement Label Database (DSLD) (https://dsld.od.nih.gov) includes full label derived information from dietary supplement products marketed in the U.S. with a Web-based user interface that provides ready access to label information. Aniline can cause skin irritation and rash. Aniline can irritate the eyes with possible eye damage. Aniline is incompatible with oxidizing agents, bases, acids, iron and iron salts, zinc, aluminium. References ^ Thomas Kahl, Kai-Wilfrid Schröder, "Aniline" in Ullmann's Encyclopedia of Industrial Chemistry 2007; John Wiley & Sons: New York. 000062-53-3 Aniline 3 27, Sup 7 1987 000090-04-0 ortho-Anisidine 2B Sup 7, 73 1999 000104-94-9 para-Anisidine 3 27, Sup 7 1987 000191-26-4 Anthanthrene 3 92, Sup 7 2010 000120-12-7 Anthracene 3 92, Sup 7 2010 000118-92-3 Anthranilic acid 3 16, Sup 7 1987 000084-65-1 Anthraquinone 2B 101 2013 001309-64-4 Antimony trioxide 2B 47 1989 001345-04-6 Antimony trisulfide 3 47 1989 000052-46-0 … CLASSIFICATION: B2; probable human carcinogen. The process for converting aniline, which has the odor of rotten fish, to a colored dye when treated by acids was discovered by accident in England in 1856. The carcinogen aniline is negative in the Ames Salmonella mutagenicity assay. In the past, benzidine was used to produce dyes or products used in clinical laboratories. Aniline can cause methemoglobin formation, and liver and endocrine effects. BUT, rats that ate food contaminated with aniline for life developed cancer of the spleen. Some authorities class aniline as a carcinogen, although the IARC lists it in Group 3 (not classifiable as to its carcinogenicity to humans) due to the limited and contradictory data available. List of Classifications. There is no legal or scientific reference or study related safe limit values for aniline. The exposure circumstance entails exposures that are carcinogenic to humans. GOTS position on Aniline Aniline is known to possess slight contact sensitising potential. EPA calculated an inhalation unit risk estimate of 4.9 × 10 -3 (µg/m 3)-1. CAS number: 62-53-3 NIOSH REL: None established; NIOSH considers aniline to be a potential occupational carcinogen as defined by the OSHA carcinogen policy [29 CFR 1990]. aniline in adult man is about 0.21 mg/kg body weight Chronic exposure Anemia, headaches, tremor, parathesia, pain, narcosis or coma, and cardiac arrhythmia. Symptoms of methemoglobinemia include cyanosis, headache, dizziness, weakness, lethargy, loss of coordination, dyspnea, coma, and death. But interestingly, we have seen that aniline has started to appear on restricted substance lists, which … The present paper shows that AZB clearly induces micronuclei in the bone marrow of rats at a dose of 375 mg/kg and above. (A substance that causes cancer or helps cancer grow is called a carcinogen.) Nitrobenzene has a synergistic effect on the toxicity of aniline and o-toluidine [5]. Aniline CAS RN: 62-53-3 Carcinogenicity Evidence. ANILINE. Aniline is an organic compound with the formula C 6 H 5 NH 2 which has the IUPAC name Phenylamine. LEL: … Exposure levels at the garment stage, especially those having undergone garment-washing processes, were low. www.efsa.europa.eu. Based on animal and human evidence, several expert agencies have evaluated the cancer-causing potential of benzene. Aniline is a chemical byproduct of treated coal tar, which was an abundant waste product of the time. Aniline has been evaluated as a carcinogen. SPECIAL PRECAUTIONS: Aniline is toxic, poisonous and a potential human carcinogen. IARC. A Heinz-body hemolytic crisis may follow the development of methemoglobinemia by 2 to 7 days. Subsequent evaluations: Vol. What are aniline dyes and how did such a plant end up in Nyack? Loading… Uses advised against Food, drug, pesticide or biocidal product use Details of the supplier of the safety data sheet Emergency Telephone Number CHEMTRECÒ, Inside the USA: 800-424-9300 CHEMTRECÒ, … Aniline poisoning is characterized by methemoglobin formation in the blood and resulting cyanosis or blue skin. Current OSHA PEL: 5 ppm (19 mg/m3) TWA [skin] 1989 OSHA PEL: 2 ppm (8 mg/m3) TWA [skin] 1993-1994 ACGIH TLV: 2 ppm (7.6 mg/m3) TWA [skin] Description of substance: Colorless to brown, oily liquid with an aromatic amine-like odor. The American Cancer Society looks to these organizations to evaluate the risks based on evidence from laboratory, animal, and human research studies. It is soluble in water, ether, ethanol and most organic solvents. Benzidine is a manufactured chemical. 1) Aniline is a skin and eye irritant and a mild dermal sensitizer. It is toxic and a suspected carcinogen which is readily absorbed by the skin. N-Nitroso-N-methylaniline (NMA) is an esophageal carcinogen in the rat. Vapour affects the eyes and lungs and reduces the ability of blood to carry oxygen. : A740I-4; A740I-500 CAS-No 62-53-3 Synonyms Phenylamine; Aminobenzene; Benzenamine (Certified ACS) Recommended Use Laboratory chemicals. The International Agency for Research on Cancer (IAR o-Toluidine is toxic and a potential human carcinogen. Based on animal studies the Panel concluded that aniline should be considered as a carcinogen [ 3 ]. 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